Aciclovir selects for ganciclovir-cross-resistance of human cytomegalovirus in vitro that is only in part explained by known mutations in the UL97 protein.

Michel, D; Höhn, S; Haller, T; Jun, D; Mertens, T

Michel, D; Höhn, S; Haller, T; Jun, D; Mertens, T.

Affiliation

Michel D; Abteilung Virologie, Universitätsklinikum Ulm, Ulm, Germany.

J Med Virol ; 65(1): 70-6, 2001 Sep.

Article in En | MEDLINE | ID: mdl-11505446

Subject(s)

Acyclovir/pharmacology; Antiviral Agents/pharmacology; Cytomegalovirus/drug effects; Ganciclovir/pharmacology; Phosphotransferases (Alcohol Group Acceptor)/genetics; Adult; Cells, Cultured; Child, Preschool; Cross Reactions; Cytomegalovirus/genetics; Cytomegalovirus/physiology; Cytomegalovirus Infections/virology; Drug Resistance, Microbial/genetics; Drug Resistance, Multiple; Female; Fibroblasts; Genotype; Humans; Infant; Male; Microbial Sensitivity Tests/methods; Mutation

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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Acyclovir / Ganciclovir / Phosphotransferases (Alcohol Group Acceptor) / Cytomegalovirus Limits: Adult / Child, preschool / Female / Humans / Infant / Male Language: En Journal: J Med Virol Year: 2001 Document type: Article

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