Carcinoembryonic antigen-specific suicide gene therapy of cytosine deaminase/5-fluorocytosine enhanced by the cre/loxP system in the orthotopic gastric carcinoma model.

Ueda, K; Iwahashi, M; Nakamori, M; Nakamura, M; Matsuura, I; Yamaue, H; Tanimura, H

Ueda, K; Iwahashi, M; Nakamori, M; Nakamura, M; Matsuura, I; Yamaue, H; Tanimura, H.

Affiliation

Ueda K; Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama 641-8510, Japan.

Cancer Res ; 61(16): 6158-62, 2001 Aug 15.

Article in En | MEDLINE | ID: mdl-11507067

Subject(s)

Antimetabolites, Antineoplastic/pharmacology; Carcinoembryonic Antigen/genetics; Flucytosine/pharmacology; Genetic Therapy/methods; Nucleoside Deaminases/genetics; Stomach Neoplasms/therapy; Adenoviridae/genetics; Animals; Antimetabolites, Antineoplastic/pharmacokinetics; Carcinoembryonic Antigen/biosynthesis; Cytosine Deaminase; Female; Flucytosine/pharmacokinetics; Gene Expression; Genetic Vectors/genetics; HeLa Cells; Humans; Integrases/genetics; Mice; Mice, Inbred BALB C; Mice, Nude; Nucleoside Deaminases/metabolism; Promoter Regions, Genetic/genetics; Stomach Neoplasms/genetics; Stomach Neoplasms/immunology; Tumor Cells, Cultured; Viral Proteins/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Genetic Therapy / Carcinoembryonic Antigen / Flucytosine / Antimetabolites, Antineoplastic / Nucleoside Deaminases Limits: Animals / Female / Humans Language: En Journal: Cancer Res Year: 2001 Document type: Article

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