Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome.

Nuyens, D; Stengl, M; Dugarmaa, S; Rossenbacker, T; Compernolle, V; Rudy, Y; Smits, J F; Flameng, W; Clancy, C E; Moons, L; Vos, M A; Dewerchin, M; Benndorf, K; Collen, D; Carmeliet, E; Carmeliet, P

Nuyens, D; Stengl, M; Dugarmaa, S; Rossenbacker, T; Compernolle, V; Rudy, Y; Smits, J F; Flameng, W; Clancy, C E; Moons, L; Vos, M A; Dewerchin, M; Benndorf, K; Collen, D; Carmeliet, E; Carmeliet, P.

Affiliation

Nuyens D; Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, Belgium.

Nat Med ; 7(9): 1021-7, 2001 Sep.

Article in En | MEDLINE | ID: mdl-11533705

Subject(s)

Arrhythmias, Cardiac/genetics; Arrhythmias, Cardiac/physiopathology; Sodium Channels/genetics; Adrenergic beta-Agonists/pharmacology; Animals; Arrhythmias, Cardiac/drug therapy; Cardiac Pacing, Artificial; Electrocardiography; Humans; Isoproterenol/pharmacology; Long QT Syndrome/genetics; Membrane Potentials; Mice; Mice, Mutant Strains; Myocardium/cytology; Myocardium/metabolism; NAV1.5 Voltage-Gated Sodium Channel; Sequence Deletion; Sodium/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Arrhythmias, Cardiac / Sodium Channels Limits: Animals / Humans Language: En Journal: Nat Med Year: 2001 Document type: Article

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