Antimalarial simplified 3-aryltrioxanes: synthesis and preclinical efficacy/toxicity testing in rodents.

Posner, G H; Jeon, H B; Parker, M H; Krasavin, M; Paik, I H; Shapiro, T A

Posner, G H; Jeon, H B; Parker, M H; Krasavin, M; Paik, I H; Shapiro, T A.

Affiliation

Posner GH; Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, Maryland 21218, USA.

J Med Chem ; 44(19): 3054-8, 2001 Sep 13.

Article in En | MEDLINE | ID: mdl-11543673

Subject(s)

Antimalarials/chemical synthesis; Benzoates/chemical synthesis; Bridged Bicyclo Compounds, Heterocyclic/chemical synthesis; Heterocyclic Compounds, 3-Ring/chemical synthesis; Animals; Antimalarials/chemistry; Antimalarials/pharmacology; Antimalarials/toxicity; Benzoates/chemistry; Benzoates/pharmacology; Benzoates/toxicity; Bridged Bicyclo Compounds, Heterocyclic/chemistry; Bridged Bicyclo Compounds, Heterocyclic/pharmacology; Bridged Bicyclo Compounds, Heterocyclic/toxicity; Drug Evaluation, Preclinical; Drug Storage; Heterocyclic Compounds, 3-Ring/chemistry; Heterocyclic Compounds, 3-Ring/pharmacology; Heterocyclic Compounds, 3-Ring/toxicity; Male; Mice; Plasmodium berghei/drug effects; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

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Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Benzoates / Bridged Bicyclo Compounds, Heterocyclic / Heterocyclic Compounds, 3-Ring / Antimalarials Limits: Animals Language: En Journal: J Med Chem Year: 2001 Document type: Article

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