Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents.

Wright, C W; Addae-Kyereme, J; Breen, A G; Brown, J E; Cox, M F; Croft, S L; Gökçek, Y; Kendrick, H; Phillips, R M; Pollet, P L

Wright, C W; Addae-Kyereme, J; Breen, A G; Brown, J E; Cox, M F; Croft, S L; Gökçek, Y; Kendrick, H; Phillips, R M; Pollet, P L.

Affiliation

Wright CW; The School of Pharmacy, University of Bradford, West Yorkshire, BD7 1DP, UK. c.w.wright@bradford.ac.uk

J Med Chem ; 44(19): 3187-94, 2001 Sep 13.

Article in En | MEDLINE | ID: mdl-11543688

Subject(s)

Alkaloids/chemistry; Alkaloids/chemical synthesis; Antimalarials/chemical synthesis; Indoles; Quinolines; Alkaloids/pharmacology; Animals; Antimalarials/chemistry; Antimalarials/pharmacology; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Cattle; DNA/chemistry; Drug Screening Assays, Antitumor; Heating; Hemin/chemistry; Indole Alkaloids; Malaria/drug therapy; Mice; Nucleic Acid Denaturation; Plasmodium berghei; Plasmodium falciparum/drug effects; Structure-Activity Relationship; Tumor Cells, Cultured

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Collection: 01-internacional Health context: 2_ODS3 / 3_ND Database: MEDLINE Main subject: Quinolines / Alkaloids / Indoles / Antimalarials Limits: Animals Language: En Journal: J Med Chem Year: 2001 Document type: Article

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