Enhanced activation of B cells in a granulocyte colony-stimulating factor-mobilized peripheral blood stem cell graft.
Br J Haematol
; 114(3): 698-700, 2001 Sep.
Article
in En
| MEDLINE
| ID: mdl-11553000
ABSTRACT
In a randomized study that compared human leucocyte antigen-identical allogeneic granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood stem cell (PBSC) versus bone marrow (BM) transplantation, the expression of activation markers, CD23, CD25 and CD45RO by B cells, was compared in blood before and after G-CSF mobilization and in PBSC versus BM grafts. The fractions of CD23+ and CD25+ B cells were higher in PBSC than in BM grafts. Moreover, we observed a G-CSF-induced increase in B-cell fractions in blood as well as in PBSC grafts when compared with BM grafts. Such an enhanced B-cell activation could contribute to the accelerated kinetics of immuno-haematological reconstitution, the occurrence of acute haemolysis in the ABO minor incompatibility setting, as well as the increased incidence of chronic graft-versus-host disease observed after PBSC transplantation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
B-Lymphocytes
/
Lymphocyte Activation
/
Granulocyte Colony-Stimulating Factor
/
Hematopoietic Stem Cell Transplantation
/
Hematopoietic Stem Cell Mobilization
Type of study:
Clinical_trials
Limits:
Humans
Language:
En
Journal:
Br J Haematol
Year:
2001
Document type:
Article