A prostaglandin E2 receptor subtype EP1 receptor antagonist (ONO-8711) reduces hyperalgesia, allodynia, and c-fos gene expression in rats with chronic nerve constriction.

Kawahara, H; Sakamoto, A; Takeda, S; Onodera, H; Imaki, J; Ogawa, R

Kawahara, H; Sakamoto, A; Takeda, S; Onodera, H; Imaki, J; Ogawa, R.

Affiliation

Kawahara H; Department of Anesthesiology, Nippon Medical School, 1-1-5, Sendagi, Bunkyoku, Tokyo, Japan. kawahara_hiroyasu/anesth@nms.ac.jp

Anesth Analg ; 93(4): 1012-7, 2001 Oct.

Article in En | MEDLINE | ID: mdl-11574375

Subject(s)

Bridged Bicyclo Compounds/pharmacology; Caproates/pharmacology; Gene Expression Regulation/drug effects; Genes, fos/drug effects; Hyperalgesia/drug therapy; Pain Measurement/drug effects; Receptors, Prostaglandin E/antagonists & inhibitors; Sciatic Nerve/physiology; Animals; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Diclofenac/pharmacology; Hot Temperature; Ligation; Male; Rats; Rats, Sprague-Dawley; Reaction Time/drug effects; Receptors, Prostaglandin E, EP1 Subtype; Spinal Cord/drug effects; Spinal Cord/metabolism

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Sciatic Nerve / Bridged Bicyclo Compounds / Pain Measurement / Caproates / Gene Expression Regulation / Genes, fos / Receptors, Prostaglandin E / Hyperalgesia Type of study: Prognostic_studies Limits: Animals Language: En Journal: Anesth Analg Year: 2001 Document type: Article

Search on Google

XML

PubMed Links