Prediction of the shelf life of cellulose acetate hemodialyzers by Monte Carlo simulation.
ASAIO J
; 47(5): 522-7, 2001.
Article
in En
| MEDLINE
| ID: mdl-11575830
ABSTRACT
A previous investigation by our laboratory linked cellulose acetate degradation with adverse health effects in hemodialysis patients. To establish the accumulation of degradation products with time, a Monte Carlo model of degradation kinetics was developed. The model tracks changes in a population of molecules representative of the dialyzer membrane during the degradation process. The degradation calculation is a two step process First, the model uses a random number to select an individual polymer molecule out of the population, and then a second random number is used to identify a site on the selected molecule for the degradation reaction to occur. After the reaction calculation, the resulting degraded molecules are redistributed into the population. The course of the reaction is determined by recalculating the molecular weight averages in the changing population as the calculations proceed. The model was validated using gel permeation chromatography molecular weight results and total acetyl content measurements on dialyzers stored up to 13.3 years after manufacture. It was found that the degradation reactions can be accurately modeled as random events and that the chain scissions and deacetylation events occur at constant rates. The shelf life of these devices was estimated using the model predictions and animal test results.
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Collection:
01-internacional
Health context:
1_ASSA2030
Database:
MEDLINE
Main subject:
Cellulose
/
Kidneys, Artificial
/
Membranes, Artificial
Type of study:
Health_economic_evaluation
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
ASAIO J
Year:
2001
Document type:
Article