Iron(II)-induced degradation of antimalarial beta-sulfonyl endoperoxides: evidence for the generation of potentially cytotoxic carbocations.

Szpilman, A M; Korshin, E E; Hoos, R; Posner, G H; Bachi, M D

Szpilman, A M; Korshin, E E; Hoos, R; Posner, G H; Bachi, M D.

Affiliation

Szpilman AM; Department of Organic Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel.

J Org Chem ; 66(20): 6531-40, 2001 Oct 05.

Article in En | MEDLINE | ID: mdl-11578201

Subject(s)

Antimalarials/metabolism; Iron/pharmacology; Peroxides/metabolism; Antimalarials/chemistry; Free Radicals/chemistry; Free Radicals/metabolism; Oxidation-Reduction; Peroxides/chemistry; Peroxides/therapeutic use; Prodrugs/chemistry; Prodrugs/metabolism; Sulfinic Acids/chemistry

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Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Peroxides / Iron / Antimalarials Language: En Journal: J Org Chem Year: 2001 Document type: Article

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