Porins from Salmonella typhimurium accelerate human blood coagulation in vitro by selective stimulation of thrombin activity: implications in septic shock DIC pathogenesis.

Di Micco, B; Metafora, S; Colonna, G; Cartenì, M; Ragone, R; Macalello, M A; Di Micco, P; Baroni, A; Catalanotti, P; Tufano, M A

Di Micco, B; Metafora, S; Colonna, G; Cartenì, M; Ragone, R; Macalello, M A; Di Micco, P; Baroni, A; Catalanotti, P; Tufano, M A.

Affiliation

Di Micco B; Dipartimento di Biochimica e Biofisica Francesco Cedrangolo and Centro di Ricerca Interdipartimentale di Scienze Computazionali e Biotecnologiche, Seconda Università degli Studi di Napoli, Napoli, Italy.

J Endotoxin Res ; 7(3): 211-7, 2001.

Article in En | MEDLINE | ID: mdl-11581572

Subject(s)

Blood Coagulation; Disseminated Intravascular Coagulation/physiopathology; Porins/metabolism; Salmonella typhimurium/metabolism; Thrombin/metabolism; Antithrombin III/metabolism; Antithrombins/metabolism; Disseminated Intravascular Coagulation/etiology; Humans; Partial Thromboplastin Time; Peptide Hydrolases/metabolism; Porins/pharmacology; Porins/physiology; Prothrombin Time; Shock, Septic/metabolism; Shock, Septic/physiopathology; Syndrome; Whole Blood Coagulation Time

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Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Salmonella typhimurium / Blood Coagulation / Thrombin / Porins / Disseminated Intravascular Coagulation Type of study: Etiology_studies Limits: Humans Language: En Journal: J Endotoxin Res Year: 2001 Document type: Article

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