An enteroaggregative Escherichia coli strain of serotype O111:H12 damages and invades cultured T84 cells and human colonic mucosa.
FEMS Microbiol Lett
; 203(2): 199-205, 2001 Sep 25.
Article
in En
| MEDLINE
| ID: mdl-11583848
ABSTRACT
The pathogenic mechanisms of enteroaggregative Escherichia coli (EAEC) are not well defined. We investigated the interaction of EAEC strain 236 (serotype O111H12) with polarised Caco-2 and T84 human intestinal epithelial cells lines, and with human jejunal and colonic mucosa. Strain 236 adhered to both polarised cell lines and to both intestinal tissue types, but caused severe damage and was invasive only in T84 cells and colonic mucosa. In contrast, prototype EAEC strain 042, which also adhered to the cultured intestinal cell lines, did not adhere to or invade jejunal or colonic tissue. These observations suggest a heterogeneity of virulence properties within the EAEC category of diarrhoea-causing E. coli.
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Collection:
01-internacional
Health context:
3_ND
Database:
MEDLINE
Main subject:
Colon
/
Escherichia coli
/
Intestinal Mucosa
Limits:
Child
/
Humans
Language:
En
Journal:
FEMS Microbiol Lett
Year:
2001
Document type:
Article