Enhanced activity of antisense phosphorothioate oligos against leishmania amastigotes: augmented uptake of oligo, ribonuclease H activation, and efficient target intervention under altered growth conditions.

Mishra, M; Porter-Kelley, J M; Singh, P K; Bennett, J R; Chaudhuri, G

Mishra, M; Porter-Kelley, J M; Singh, P K; Bennett, J R; Chaudhuri, G.

Affiliation

Mishra M; Department of Microbiology, Meharry Medical College, Nashville, TN 37208, USA.

Biochem Pharmacol ; 62(5): 569-80, 2001 Sep 01.

Article in En | MEDLINE | ID: mdl-11585054

Subject(s)

Leishmania/drug effects; Oligodeoxyribonucleotides, Antisense/pharmacology; Polylysine/pharmacology; Ribonuclease H/metabolism; Thionucleotides/pharmacology; Animals; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Drug Interactions; Enzyme Activation; Germ-Free Life/drug effects; Hydrogen-Ion Concentration; Leishmania/metabolism; Leishmaniasis/drug therapy; Liposomes; Luciferases/biosynthesis; Luciferases/drug effects; Macrophages/drug effects; Macrophages/parasitology; Mice; Mice, Inbred BALB C; Oligodeoxyribonucleotides, Antisense/pharmacokinetics; Oligodeoxyribonucleotides, Antisense/therapeutic use; Parasitic Sensitivity Tests; Phagosomes/drug effects; Phagosomes/parasitology; Temperature; Thionucleotides/pharmacokinetics; Thionucleotides/therapeutic use; Transfection

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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Polylysine / Thionucleotides / Ribonuclease H / Oligodeoxyribonucleotides, Antisense / Leishmania Type of study: Prognostic_studies Limits: Animals Language: En Journal: Biochem Pharmacol Year: 2001 Document type: Article

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