CHF-1024, a DA2/alpha2 agonist, blunts norepinephrine excretion and cardiac fibrosis in pressure overload.

Masson, S; Chimenti, S; Salio, M; Torri, M; Limana, F; Bernasconi, R; Calvillo, L; Santambrogio, D; Gagliano, N; Arosio, B; Annoni, G; Razzetti, R; Bongrani, S; Latini, R

Masson, S; Chimenti, S; Salio, M; Torri, M; Limana, F; Bernasconi, R; Calvillo, L; Santambrogio, D; Gagliano, N; Arosio, B; Annoni, G; Razzetti, R; Bongrani, S; Latini, R.

Affiliation

Masson S; Department of Cardiovascular Research, Istituto di Ricerche Farmcologiche-Mario Negri, Milan, Italy.

Cardiovasc Drugs Ther ; 15(2): 131-8, 2001 Mar.

Article in En | MEDLINE | ID: mdl-11669406

Subject(s)

Adrenergic alpha-Agonists/pharmacology; Angiotensin-Converting Enzyme Inhibitors/pharmacology; Aortic Valve Stenosis/prevention & control; Captopril/pharmacology; Cardiomyopathy, Hypertrophic/drug therapy; Norepinephrine/urine; Tetrahydronaphthalenes/pharmacology; Adrenergic alpha-Agonists/administration & dosage; Adrenergic alpha-Agonists/therapeutic use; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors/therapeutic use; Animals; Captopril/therapeutic use; Cardiomyopathy, Hypertrophic/metabolism; Dose-Response Relationship, Drug; Hemodynamics/drug effects; Hypertension, Renal/drug therapy; Ligation; Male; Rats; Rats, Sprague-Dawley; Tetrahydronaphthalenes/administration & dosage; Tetrahydronaphthalenes/therapeutic use

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Collection: 01-internacional Database: MEDLINE Main subject: Aortic Valve Stenosis / Tetrahydronaphthalenes / Cardiomyopathy, Hypertrophic / Angiotensin-Converting Enzyme Inhibitors / Captopril / Norepinephrine / Adrenergic alpha-Agonists Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cardiovasc Drugs Ther Year: 2001 Document type: Article

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