Oligonucleotides with bistranded abasic sites interfere with substrate binding and catalysis by human apurinic/apyrimidinic endonuclease.

McKenzie, J A; Strauss, P R

McKenzie, J A; Strauss, P R.

Affiliation

McKenzie JA; Department of Biology, Northeastern University, Boston, Massachusetts 02115, USA.

Biochemistry ; 40(44): 13254-61, 2001 Nov 06.

Article in En | MEDLINE | ID: mdl-11683634

Subject(s)

Base Pairing/genetics; Carbon-Oxygen Lyases/metabolism; DNA/metabolism; Binding Sites; Catalysis; DNA Damage; DNA-(Apurinic or Apyrimidinic Site) Lyase; Deoxyribonuclease IV (Phage T4-Induced); Enzyme Stability; Humans; Kinetics; Models, Chemical; Recombinant Proteins/metabolism; Substrate Specificity

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: DNA / Carbon-Oxygen Lyases / Base Pairing Limits: Humans Language: En Journal: Biochemistry Year: 2001 Document type: Article

Search on Google

XML

PubMed Links