Lovastatin-induced apoptosis in thyroid cells: involvement of cytochrome c and lamin B.

Di Matola, T; D'Ascoli, F; Luongo, C; Bifulco, M; Rossi, G; Fenzi, G; Vitale, M

Di Matola, T; D'Ascoli, F; Luongo, C; Bifulco, M; Rossi, G; Fenzi, G; Vitale, M.

Affiliation

Di Matola T; Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Via S Pansini 5, 80131, Naples, Italy.

Eur J Endocrinol ; 145(5): 645-50, 2001 Nov.

Article in En | MEDLINE | ID: mdl-11720884

Subject(s)

Apoptosis/drug effects; Cytochrome c Group/metabolism; Lovastatin/pharmacology; Nuclear Proteins/metabolism; Thyroid Gland/cytology; Antibodies, Monoclonal; Blotting, Western; Caspase 2; Caspase 3; Caspase 6; Caspases/metabolism; Cells, Cultured; Cytosol/enzymology; Enzyme Activation/drug effects; Genes, bcl-2/genetics; Genes, p53/genetics; Humans; Lamin Type B; Lamins; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins c-bcl-2/genetics; Thyroid Gland/drug effects; Thyroid Gland/enzymology; Up-Regulation/drug effects; bcl-2-Associated X Protein; bcl-X Protein

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Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Thyroid Gland / Lovastatin / Nuclear Proteins / Apoptosis / Cytochrome c Group Limits: Humans Language: En Journal: Eur J Endocrinol Year: 2001 Document type: Article

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