Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.

Thummel, K E; Brimer, C; Yasuda, K; Thottassery, J; Senn, T; Lin, Y; Ishizuka, H; Kharasch, E; Schuetz, J; Schuetz, E

Thummel, K E; Brimer, C; Yasuda, K; Thottassery, J; Senn, T; Lin, Y; Ishizuka, H; Kharasch, E; Schuetz, J; Schuetz, E.

Affiliation

Thummel KE; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.

Mol Pharmacol ; 60(6): 1399-406, 2001 Dec.

Article in En | MEDLINE | ID: mdl-11723248

Subject(s)

Calcitriol/pharmacology; Cytochrome P-450 Enzyme System/biosynthesis; Intestines/drug effects; Mixed Function Oxygenases/biosynthesis; Transcription, Genetic/drug effects; Animals; COS Cells; Caco-2 Cells; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System/genetics; Dimerization; Dose-Response Relationship, Drug; Enzyme Induction; Ergocalciferols/pharmacology; Haplorhini; Humans; Intestines/enzymology; Luciferases/genetics; Mixed Function Oxygenases/genetics; Pregnane X Receptor; Protein Binding; Receptors, Calcitriol/genetics; Receptors, Calcitriol/metabolism; Receptors, Cytoplasmic and Nuclear/metabolism; Receptors, Retinoic Acid/metabolism; Receptors, Steroid/metabolism; Retinoid X Receptors; Time Factors; Transcription Factors/metabolism; Transcriptional Activation

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Collection: 01-internacional Database: MEDLINE Main subject: Transcription, Genetic / Calcitriol / Cytochrome P-450 Enzyme System / Mixed Function Oxygenases / Intestines Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Pharmacol Year: 2001 Document type: Article

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