Novel tropane-based irreversible ligands for the dopamine transporter.

Zou, M F; Kopajtic, T; Katz, J L; Wirtz, S; Justice, J B; Newman, A H

Zou, M F; Kopajtic, T; Katz, J L; Wirtz, S; Justice, J B; Newman, A H.

Affiliation

Zou MF; Medicinal Chemistry Section, National Institute on Drug Abuse-Intramural Research Program, Baltimore, Maryland 21131, USA.

J Med Chem ; 44(25): 4453-61, 2001 Dec 06.

Article in En | MEDLINE | ID: mdl-11728190

Subject(s)

Benztropine/analogs & derivatives; Benztropine/chemical synthesis; Cocaine/analogs & derivatives; Dopamine Uptake Inhibitors/chemical synthesis; Dopamine/metabolism; Isothiocyanates/chemical synthesis; Membrane Glycoproteins; Membrane Transport Proteins/metabolism; Nerve Tissue Proteins; Tropanes/chemical synthesis; Animals; Azides/metabolism; Benztropine/chemistry; Benztropine/metabolism; Binding, Competitive; Cell Line; Cocaine/metabolism; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors/chemistry; Dopamine Uptake Inhibitors/metabolism; Humans; In Vitro Techniques; Isothiocyanates/chemistry; Isothiocyanates/metabolism; Ligands; Male; Putamen/metabolism; Radioligand Assay; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tropanes/chemistry; Tropanes/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Tropanes / Membrane Glycoproteins / Benztropine / Dopamine / Cocaine / Isothiocyanates / Dopamine Uptake Inhibitors / Nerve Tissue Proteins Limits: Animals / Humans / Male Language: En Journal: J Med Chem Year: 2001 Document type: Article

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