Influenza vaccination of HIV-1-positive and HIV-1-negative former intravenous drug users.
J Med Virol
; 65(4): 644-8, 2001 Dec.
Article
in En
| MEDLINE
| ID: mdl-11745926
ABSTRACT
The immunogenicity of an anti-influenza vaccine was assessed in 409 former intravenous drug user volunteers and its effect on the levels of HIV-1 RNA, proviral DNA and on CD4+ lymphocyte counts in a subset HIV-1-positive subjects was measured. HIV-1-positive individuals (n = 72) were divided into three groups on the basis of their CD4+ lymphocyte counts, while the 337 HIV-1-negative participants were allocated into group four. Haemagglutination inhibiting (HI) responses varied from 45.8 to 70% in the HIV-1-positive subjects and were significantly higher in group four (80.7% responses to the H1N1 strain, 81.6% to the H3N2 strain, and 83% to the B strain). The percentage of subjects with HI protective antibody titres (> or = 140) increased significantly after vaccination, especially in HIV-1 uninfected subjects. Immunization caused no significant changes in CD4+ counts and in neither plasma HIV-1 RNA nor proviral DNA levels. Therefore, vaccination against influenza may benefit persons infected by HIV-1.
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Collection:
01-internacional
Health context:
2_ODS3
Database:
MEDLINE
Main subject:
Orthomyxoviridae
/
Influenza Vaccines
/
HIV Infections
/
Substance Abuse, Intravenous
/
HIV-1
/
HIV Seropositivity
/
Influenza, Human
/
Antibodies, Viral
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Med Virol
Year:
2001
Document type:
Article