Performance decrement after combined exposure to ionizing radiation and Shigella sonnei.
Mil Med
; 166(12 Suppl): 71-3, 2001 Dec.
Article
in En
| MEDLINE
| ID: mdl-11778444
ABSTRACT
Ionizing radiation could increase morbidity from common bacterial infections in military personnel on the modern battlefield. The combined effects of a sublethal dose of ionizing radiation and the bacterial diarrheal agent Shigella sonnei on body weight and forelimb grip strength in mice were assessed over a 30-day period. Individually housed B6D2F1 female mice were divided into four groups control, sham irradiation + gavage with saline vehicle; 3 Gy 60Co gamma radiation at 0.4 Gy/min radiation + saline gavage; sham irradiation + 1.3 x 10(8) colony-forming units (CFUs) S. sonnei via gavage, administered 4 days postirradiation; and the combination of 3 Gy 60Co gamma radiation + 1.3 x 10(8) CFUs S. sonnei. Behavioral tests were conducted 3 days preirradiation and on days 9, 14, and 22 postirradiation. Body weight was significantly reduced in the radiation + Shigella group on days 5 to 10 postirradiation. Forelimb grip strength was reduced for mice in the radiation + Shigella group on days 9 and 14 postirradiation. These data demonstrate that an exposure to gamma radiation in combination with the bacterial agent S. sonnei can lead to a synergistic loss of body weight and degradation in performance.
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Collection:
01-internacional
Health context:
3_ND
Database:
MEDLINE
Main subject:
Shigella sonnei
/
Weight Loss
/
Dysentery, Bacillary
/
Gamma Rays
Limits:
Animals
Language:
En
Journal:
Mil Med
Year:
2001
Document type:
Article