Developmental expression profiles of Celsr (Flamingo) genes in the mouse.
Mech Dev
; 112(1-2): 157-60, 2002 Mar.
Article
in En
| MEDLINE
| ID: mdl-11850187
ABSTRACT
Celsr, also called Flamingo (Fmi) genes encode proteins of the cadherin superfamily. Celsr cadherins are seven-pass transmembrane proteins with nine cadherin repeats in the extracellular domain, and an anonymous intracellular C-terminus. The Drosophila Fmi gene regulates epithelial planar cell polarity and dendritic field deployment. The three Flamingo gene orthologs in man and rodents are named, respectively, CELSR1-3 and Celsr1-3. Celsr1 and 2 are expressed during early development, in the brain and epithelia. In this report, we characterized further Celsr genes in the mouse, and examined their developmental pattern of expression. Each Celsr is expressed prominently in the developing brain following a specific pattern, suggesting that they serve distinct functions.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Cadherins
/
Receptors, Cell Surface
/
Receptors, G-Protein-Coupled
/
Fetal Proteins
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Mech Dev
Year:
2002
Document type:
Article