Regional variations in the distributions of small intestinal intraepithelial lymphocytes (IELs) in BALB/c +/+, nu/+, and nu/nu mice.
Comp Med
; 51(2): 127-33, 2001 Apr.
Article
in En
| MEDLINE
| ID: mdl-11922175
ABSTRACT
Regional variations in intraepithelial lymphocytes (IELs) in the small intestine were examined in BALB/c +/+, nu/+, and nu/nu mice. The small intestine was obtained from 11- to 12-week-old mice and divided equally into three (proximal, middle, and distal) parts. The IELs were isolated from each part of the intestine, and the total numbers of IELs in nu/+ and nu/nu mice were about a fifth of those in +/+ mice. Regional variations in the distribution of the IEL alphabeta, but not the gammadelta T-cell subset were found by use of flow cytometry in +/+ and nu/+ mice. On the other hand, such differences were not found in nu/nu mice, suggesting that thymus-independent development of T cells is not different among regions. Different local expansion of thymus-dependent alphabeta T cells may cause the regional variations seen in the distribution of alphabeta T cell IELs in +/+ and nu/+ mice.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rodent Diseases
/
T-Lymphocyte Subsets
/
Lymphocyte Count
/
Immunologic Deficiency Syndromes
/
Intestine, Small
/
Mice, Inbred BALB C
/
Mice, Nude
Limits:
Animals
Language:
En
Journal:
Comp Med
Year:
2001
Document type:
Article