Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

Chanas, Simon A; Jiang, Qing; McMahon, Michael; McWalter, Gail K; McLellan, Lesley I; Elcombe, Clifford R; Henderson, Colin J; Wolf, C Roland; Moffat, Graeme J; Itoh, Ken; Yamamoto, Masayuki; Hayes, John D

Chanas, Simon A; Jiang, Qing; McMahon, Michael; McWalter, Gail K; McLellan, Lesley I; Elcombe, Clifford R; Henderson, Colin J; Wolf, C Roland; Moffat, Graeme J; Itoh, Ken; Yamamoto, Masayuki; Hayes, John D.

Affiliation

Chanas SA; Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK.

Biochem J ; 365(Pt 2): 405-16, 2002 Jul 15.

Article in En | MEDLINE | ID: mdl-11991805

Subject(s)

DNA-Binding Proteins/physiology; Glutathione Transferase/genetics; Liver/enzymology; Trans-Activators/physiology; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cloning, Molecular; DNA Primers; DNA Probes; DNA-Binding Proteins/genetics; Female; Glutathione Transferase/chemistry; Glutathione Transferase/metabolism; Male; Mice; Mice, Knockout; Molecular Sequence Data; NF-E2-Related Factor 2; RNA, Messenger/genetics; Sequence Homology, Amino Acid; Trans-Activators/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trans-Activators / DNA-Binding Proteins / Glutathione Transferase / Liver Type of study: Etiology_studies Limits: Animals Language: En Journal: Biochem J Year: 2002 Document type: Article

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