Pharmacology of beta-L-thymidine and beta-L-2'-deoxycytidine in HepG2 cells and primary human hepatocytes: relevance to chemotherapeutic efficacy against hepatitis B virus.

Hernandez-Santiago, B; Placidi, L; Cretton-Scott, E; Faraj, A; Bridges, E G; Bryant, M L; Rodriguez-Orengo, J; Imbach, J L; Gosselin, G; Pierra, C; Dukhan, D; Sommadossi, J P

Hernandez-Santiago, B; Placidi, L; Cretton-Scott, E; Faraj, A; Bridges, E G; Bryant, M L; Rodriguez-Orengo, J; Imbach, J L; Gosselin, G; Pierra, C; Dukhan, D; Sommadossi, J P.

Affiliation

Hernandez-Santiago B; Department of Pharmacology, University of Alabama at Birmingham, USA.

Antimicrob Agents Chemother ; 46(6): 1728-33, 2002 Jun.

Article in En | MEDLINE | ID: mdl-12019082

Subject(s)

Antiviral Agents/pharmacology; Carcinoma, Hepatocellular/metabolism; Deoxycytidine/pharmacology; Hepatitis B virus/drug effects; Hepatitis B/drug therapy; Hepatocytes/drug effects; Liver Neoplasms/metabolism; Thymidine/pharmacology; Chromatography, High Pressure Liquid; Deoxycytidine/metabolism; Half-Life; Hepatitis B/virology; Humans; Phosphorylation; Thymidine/metabolism; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Thymidine / Hepatitis B virus / Carcinoma, Hepatocellular / Hepatocytes / Deoxycytidine / Hepatitis B / Liver Neoplasms Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2002 Document type: Article

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