Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism.

Peters, G J; Backus, H H J; Freemantle, S; van Triest, B; Codacci-Pisanelli, G; van der Wilt, C L; Smid, K; Lunec, J; Calvert, A H; Marsh, S; McLeod, H L; Bloemena, E; Meijer, S; Jansen, G; van Groeningen, C J; Pinedo, H M

Peters, G J; Backus, H H J; Freemantle, S; van Triest, B; Codacci-Pisanelli, G; van der Wilt, C L; Smid, K; Lunec, J; Calvert, A H; Marsh, S; McLeod, H L; Bloemena, E; Meijer, S; Jansen, G; van Groeningen, C J; Pinedo, H M.

Affiliation

Peters GJ; Department of Medical Oncology, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands. gj.peters@vumc.nl

Biochim Biophys Acta ; 1587(2-3): 194-205, 2002 Jul 18.

Article in En | MEDLINE | ID: mdl-12084461

Subject(s)

Fluorouracil/pharmacology; Thymidylate Synthase/biosynthesis; Animals; Antimetabolites, Antineoplastic/metabolism; Antimetabolites, Antineoplastic/pharmacology; Drug Resistance, Neoplasm/physiology; Enzyme Induction/drug effects; Fluorouracil/metabolism; Folic Acid Antagonists/pharmacology; Humans; In Vitro Techniques; Neoplasms/drug therapy; Neoplasms/enzymology; Neoplasms/genetics; Polymorphism, Genetic; Promoter Regions, Genetic; RNA, Messenger/genetics; RNA, Messenger/metabolism; RNA, Neoplasm/genetics; RNA, Neoplasm/metabolism; Thymidylate Synthase/antagonists & inhibitors; Thymidylate Synthase/genetics; Tumor Cells, Cultured; Tumor Suppressor Protein p53/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Thymidylate Synthase / Fluorouracil Type of study: Guideline / Observational_studies Limits: Animals / Humans Language: En Journal: Biochim Biophys Acta Year: 2002 Document type: Article

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