Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance.

Rizzi, Massimo; Caccia, Silvio; Guiso, Giovanna; Richichi, Cristina; Gorter, Jan A; Aronica, Eleonora; Aliprandi, Marisa; Bagnati, Renzo; Fanelli, Roberto; D'Incalci, Maurizio; Samanin, Rosario; Vezzani, Annamaria

Rizzi, Massimo; Caccia, Silvio; Guiso, Giovanna; Richichi, Cristina; Gorter, Jan A; Aronica, Eleonora; Aliprandi, Marisa; Bagnati, Renzo; Fanelli, Roberto; D'Incalci, Maurizio; Samanin, Rosario; Vezzani, Annamaria.

Affiliation

Rizzi M; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milano, Italy.

J Neurosci ; 22(14): 5833-9, 2002 Jul 15.

Article in En | MEDLINE | ID: mdl-12122045

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Brain/physiopathology; Drug Resistance; Seizures/physiopathology; ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics; Animals; Anticonvulsants/pharmacokinetics; Anticonvulsants/pharmacology; Brain/drug effects; Brain/metabolism; Disease Models, Animal; Drug Resistance/physiology; Electric Stimulation; Electroencephalography; Entorhinal Cortex/drug effects; Entorhinal Cortex/metabolism; Gene Expression/drug effects; Hippocampus/drug effects; Hippocampus/metabolism; Homozygote; Limbic System/drug effects; Limbic System/metabolism; Limbic System/physiopathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Messenger/metabolism; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Seizures / Brain / Drug Resistance / ATP Binding Cassette Transporter, Subfamily B, Member 1 Limits: Animals Language: En Journal: J Neurosci Year: 2002 Document type: Article

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