Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of an acyloxyalkoxy-based cyclic prodrug of the opioid peptide DADLE.

Tang, Fuxing; Borchardt, Ronald T

Tang, Fuxing; Borchardt, Ronald T.

Affiliation

Tang F; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence 66047, USA.

Pharm Res ; 19(6): 780-6, 2002 Jun.

Article in En | MEDLINE | ID: mdl-12134947

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Enkephalin, Leucine-2-Alanine/pharmacokinetics; Genes, MDR/physiology; Intestinal Mucosa/metabolism; Mitochondrial Proteins; Prodrugs/pharmacokinetics; Ribosomal Proteins/metabolism; Saccharomyces cerevisiae Proteins; Animals; Caco-2 Cells; Cell Line; Dogs; Enkephalin, Leucine-2-Alanine/chemistry; Humans; Multidrug Resistance-Associated Protein 2; Opioid Peptides/pharmacokinetics; Permeability/drug effects; Prodrugs/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Ribosomal Proteins / Prodrugs / Enkephalin, Leucine-2-Alanine / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Genes, MDR / Saccharomyces cerevisiae Proteins / Mitochondrial Proteins / Intestinal Mucosa Limits: Animals / Humans Language: En Journal: Pharm Res Year: 2002 Document type: Article

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