A modified coumarinic acid-based cyclic prodrug of an opioid peptide: its enzymatic and chemical stability and cell permeation characteristics.

Ouyang, Hui; Tang, Fuxing; Siahaan, Teruna J; Borchardt, Ronald T

Ouyang, Hui; Tang, Fuxing; Siahaan, Teruna J; Borchardt, Ronald T.

Affiliation

Ouyang H; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence 66049, USA.

Pharm Res ; 19(6): 794-801, 2002 Jun.

Article in En | MEDLINE | ID: mdl-12134949

Subject(s)

Enkephalin, Leucine-2-Alanine/chemistry; Mitochondrial Proteins; Prodrugs/chemistry; Saccharomyces cerevisiae Proteins; Acids/chemistry; Acids/metabolism; Animals; Caco-2 Cells; Cell Line; Coumarins/chemistry; Coumarins/pharmacokinetics; Dogs; Enkephalin, Leucine-2-Alanine/pharmacokinetics; Enzyme Stability/drug effects; Enzyme Stability/physiology; Genes, MDR/physiology; Humans; Liver/enzymology; Male; Multidrug Resistance-Associated Protein 2; Permeability/drug effects; Prodrugs/pharmacokinetics; Rats; Rats, Sprague-Dawley; Ribosomal Proteins/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Enkephalin, Leucine-2-Alanine / Saccharomyces cerevisiae Proteins / Mitochondrial Proteins Limits: Animals / Humans / Male Language: En Journal: Pharm Res Year: 2002 Document type: Article

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