Modulation of glucocorticoid-induced GAD expression in pancreatic beta-cells by transcriptional activation of the GAD67 promoter and its possible effect on the development of diabetes.

Kim, Kyung Soo; Kang, Yup; Choi, Sung E; Kim, Ju Hee; Kim, Hyeon Man; Sun, Beichen; Jun, Hee-Sook; Yoon, Ji-Won

Kim, Kyung Soo; Kang, Yup; Choi, Sung E; Kim, Ju Hee; Kim, Hyeon Man; Sun, Beichen; Jun, Hee-Sook; Yoon, Ji-Won.

Affiliation

Kim KS; Laboratory of Endocrinology, Institute for Medical Sciences, Suwon, Republic of Korea.

Diabetes ; 51(9): 2764-72, 2002 Sep.

Article in En | MEDLINE | ID: mdl-12196470

Subject(s)

Diabetes Mellitus, Type 1/etiology; Glucocorticoids/pharmacology; Glutamate Decarboxylase/genetics; Glutamate Decarboxylase/metabolism; Islets of Langerhans/metabolism; Isoenzymes/genetics; Promoter Regions, Genetic/physiology; Transcriptional Activation/physiology; Animals; Animals, Newborn/physiology; Dexamethasone/administration & dosage; Dexamethasone/pharmacology; Diabetes Mellitus, Type 1/genetics; Dose-Response Relationship, Drug; Glucocorticoids/administration & dosage; Hydrocortisone/pharmacology; Isoenzymes/metabolism; Mice; Mice, Inbred NOD; RNA, Messenger/metabolism; Time Factors; Tumor Cells, Cultured; Up-Regulation

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Collection: 01-internacional Database: MEDLINE Main subject: Transcriptional Activation / Islets of Langerhans / Promoter Regions, Genetic / Diabetes Mellitus, Type 1 / Glucocorticoids / Glutamate Decarboxylase / Isoenzymes Limits: Animals Language: En Journal: Diabetes Year: 2002 Document type: Article

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