Subchronic toxicity of chloral hydrate on rats: a drinking water study.

Poon, R; Nakai, J; Yagminas, A; Benoit, F; Moir, D; Chu, I; Valli, V E

Poon, R; Nakai, J; Yagminas, A; Benoit, F; Moir, D; Chu, I; Valli, V E.

Affiliation

Poon R; Environmental Health Science Bureau, Health Canada, Ottawa, Canada K1A 0L2. raymond_poon@hc-sc.gc.ca

J Appl Toxicol ; 22(4): 227-36, 2002.

Article in En | MEDLINE | ID: mdl-12210539

Subject(s)

Chloral Hydrate/toxicity; Water Pollutants, Chemical/toxicity; Administration, Oral; Aldehyde Dehydrogenase/antagonists & inhibitors; Aldehyde Dehydrogenase/metabolism; Aniline Hydroxylase/metabolism; Animals; Catalase/metabolism; Chloral Hydrate/administration & dosage; Dose-Response Relationship, Drug; Enzyme Inhibitors/administration & dosage; Enzyme Inhibitors/toxicity; Female; Liver/drug effects; Liver/enzymology; Male; Myelin Sheath/drug effects; Myelin Sheath/pathology; No-Observed-Adverse-Effect Level; Optic Nerve/drug effects; Optic Nerve/pathology; Rats; Rats, Sprague-Dawley; Trichloroacetic Acid/blood; Vacuoles/drug effects; Vacuoles/pathology; Water Pollutants, Chemical/administration & dosage; Water Supply

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Collection: 01-internacional Health context: 2_ODS3 Database: MEDLINE Main subject: Water Pollutants, Chemical / Chloral Hydrate Limits: Animals Language: En Journal: J Appl Toxicol Year: 2002 Document type: Article

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