Long-term potentiation in aged rats is restored when the age-related decrease in polyunsaturated fatty acid concentration is reversed.

Martin, D S D; Spencer, P; Horrobin, D F; Lynch, M A

Martin, D S D; Spencer, P; Horrobin, D F; Lynch, M A.

Affiliation

Martin DS; Department of Physiology, Trinity College, Dublin, Ireland.

Prostaglandins Leukot Essent Fatty Acids ; 67(2-3): 121-30, 2002.

Article in En | MEDLINE | ID: mdl-12324230

Subject(s)

Aging/metabolism; Fatty Acids, Unsaturated/metabolism; Long-Term Potentiation/physiology; Animals; Arachidonic Acid/analysis; Diet; Excitatory Postsynaptic Potentials/physiology; Fatty Acids, Omega-3/administration & dosage; Fatty Acids, Omega-3/pharmacology; Fatty Acids, Unsaturated/analysis; Glutamic Acid/metabolism; Glutathione Peroxidase/metabolism; Hippocampus/chemistry; Long-Term Potentiation/drug effects; Male; Potassium Chloride/pharmacology; Rats; Rats, Wistar; Reactive Oxygen Species/metabolism; Superoxide Dismutase/metabolism; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Aging / Long-Term Potentiation / Fatty Acids, Unsaturated Type of study: Prognostic_studies Limits: Animals Language: En Journal: Prostaglandins Leukot Essent Fatty Acids Year: 2002 Document type: Article

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