Dietary sodium modification and experimental radiation nephropathy.
Int J Radiat Biol
; 78(10): 903-11, 2002 Oct.
Article
in En
| MEDLINE
| ID: mdl-12465655
ABSTRACT
PURPOSE:
To determine whether suppression of the renin-angiotensin system (RAS) with high dietary sodium (salt) has the same beneficial effect on radiation nephropathy as suppression of the RAS with angiotensin-converting-enzyme (ACE) inhibitors or angiotensin II (AII) receptor antagonists. MATERIALS ANDMETHODS:
Normal and irradiated rats were placed on high- or low-salt diets and assessed for effects on blood pressure, on AII levels and on the development of radiation nephropathy.RESULTS:
In unirradiated animals, a high-salt diet suppressed AII and caused hypertension, while a low-salt diet produced no detectable effects. Use of a high-salt diet 3-9 weeks after irradiation exacerbated radiation-induced hypertension but attenuated the development of radiation nephropathy. Continuous use of a high-salt diet slowed the progression of radiation nephropathy, but eventually exacerbated radiation-induced hypertension and accelerated renal failure. Use of a high-salt diet in animals with established radiation nephropathy was deleterious. A low-salt diet had no effect on the development of radiation nephropathy.CONCLUSIONS:
These studies provide further support for the hypothesis that the beneficial effect of AII receptor antagonists, ACE inhibitors and high dietary sodium in the prophylaxis of radiation nephropathy is due to their suppression of the RAS, not to their anti-hypertensive effects.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sodium Chloride
/
Diet, Sodium-Restricted
/
Kidney
Limits:
Animals
Language:
En
Journal:
Int J Radiat Biol
Year:
2002
Document type:
Article