Homologues and isomers of noladin ether, a putative novel endocannabinoid: interaction with rat cannabinoid CB(1) receptors.
Bioorg Med Chem Lett
; 13(1): 43-6, 2003 Jan 06.
Article
in En
| MEDLINE
| ID: mdl-12467613
Two regioisomers and 13 analogues of the putative endocannabinoid noladin ether (2-arachidonyl glyceryl ether, 2-AGE, 1) were synthesized and tested for their interaction with CB(1) receptors in rat brain membranes. The results showed that a C-20 tetra-unsaturated moiety is necessary for high affinity, and that a series of alkyl glyceryl ethers of potential occurrence in brain tissues have less affinity than 2-AGE for CB(1) receptors.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Drug
/
Fatty Acids, Unsaturated
/
Glycerides
Limits:
Animals
Language:
En
Journal:
Bioorg Med Chem Lett
Year:
2003
Document type:
Article