Effect of mercuric chloride on membrane-bound enzymes in rat testis.
Asian J Androl
; 4(4): 309-11, 2002 Dec.
Article
in En
| MEDLINE
| ID: mdl-12508136
AIM: To study the effect of mercuric chloride on the membrane-bound enzymes. METHODS: The effect of mercuric chloride at two different doses, 1 mg/kg (low dose) and 2 mg/kg (high dose), orally for 30 days, was observed on the membrane-bound enzymes in the testis of adult albino rats. RESULTS: Mercuric chloride significantly decreased the body weight and testis weight in the high dose group (P< 0.05), but not in the low dose group. The activities of 5'nucleotidase and adenosine triphosphatases were markedly decreased (P< 0.01) in the testis of both groups. Alkaline phosphatase and ggr-glutamyl transferase activities were significantly increased (P< 0.01) in both groups. However, the effect was more pronounced in the high than in the low dose groups. CONCLUSION: The dose dependent effect of mercuric chloride on these enzymes may affect the membrane characteristics and thereby the fertility of the animal.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Testis
/
Mercuric Chloride
Limits:
Animals
Language:
En
Journal:
Asian J Androl
Year:
2002
Document type:
Article