Notch, a unifying target in T-cell acute lymphoblastic leukemia?
Trends Mol Med
; 9(1): 30-5, 2003 Jan.
Article
in En
| MEDLINE
| ID: mdl-12524208
The expression of both Notch3 and pre-T-cell-receptor (pre-TCR) invariant chain appears to be a common feature of all T-cell acute lymphoblastic leukemias (T-ALL). Notch genes, and other genes that are dysregulated in some T-ALL subgroups, encode factors that play a crucial role in both T-cell development and leukemogenesis. A complex network of signals, involving Notchs, pre-TCR, nuclear factor kappaB and E2A, appears to be responsible for the leukemogenesis process. Thus, T-ALL is a paradigm for developmental pathways that underlie the pathogenesis of this disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leukemia, T-Cell
/
Proto-Oncogene Proteins
/
Receptors, Cell Surface
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Membrane Proteins
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Mol Med
Year:
2003
Document type:
Article