Long-term replacement of a mutated nonfunctional CNS gene: reversal of hypothalamic diabetes insipidus using an EIAV-based lentiviral vector expressing arginine vasopressin.

Bienemann, Alison S; Martin-Rendon, Enca; Cosgrave, Anna S; Glover, Colin P J; Wong, Liang-Fong; Kingsman, Susan M; Mitrophanous, Kyriacos A; Mazarakis, Nicholas D; Uney, James B

Bienemann, Alison S; Martin-Rendon, Enca; Cosgrave, Anna S; Glover, Colin P J; Wong, Liang-Fong; Kingsman, Susan M; Mitrophanous, Kyriacos A; Mazarakis, Nicholas D; Uney, James B.

Affiliation

Bienemann AS; MRC Centre for Synaptic Plasticity and University Research Centre for Neuroendocrinology, University of Bristol, Marlborough Street, United Kingdom.

Mol Ther ; 7(5 Pt 1): 588-96, 2003 May.

Article in En | MEDLINE | ID: mdl-12718901

Subject(s)

Arginine Vasopressin/genetics; Diabetes Insipidus, Neurogenic/therapy; Genetic Therapy; Genetic Vectors; Infectious Anemia Virus, Equine/genetics; Supraoptic Nucleus/metabolism; Animals; Arginine Vasopressin/metabolism; Diabetes Insipidus, Neurogenic/metabolism; Diabetes Insipidus, Neurogenic/pathology; Homeostasis; Humans; In Situ Hybridization; Male; Rats; Rats, Brattleboro; Rats, Inbred WKY; Supraoptic Nucleus/pathology; Time Factors; Vasoconstrictor Agents/metabolism; Water/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Supraoptic Nucleus / Arginine Vasopressin / Genetic Therapy / Infectious Anemia Virus, Equine / Diabetes Insipidus, Neurogenic / Genetic Vectors Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Mol Ther Year: 2003 Document type: Article

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