How useful is the "cocktail approach" for evaluating human hepatic drug metabolizing capacity using cytochrome P450 phenotyping probes in vivo?

Tanaka, E; Kurata, N; Yasuhara, H

Tanaka, E; Kurata, N; Yasuhara, H.

Affiliation

Tanaka E; Institute of Community Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki-ken 305-8575, Japan. einosuke@md.tsukuba.ac.jp

J Clin Pharm Ther ; 28(3): 157-65, 2003 Jun.

Article in En | MEDLINE | ID: mdl-12795773

Subject(s)

Cytochrome P-450 Enzyme System/metabolism; Liver/enzymology; Pharmaceutical Preparations/metabolism; Phenotype; Aryl Hydrocarbon Hydroxylases/genetics; Aryl Hydrocarbon Hydroxylases/metabolism; Cytochrome P-450 CYP1A2/genetics; Cytochrome P-450 CYP1A2/metabolism; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6/genetics; Cytochrome P-450 CYP2D6/metabolism; Cytochrome P-450 CYP2E1/genetics; Cytochrome P-450 CYP2E1/metabolism; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System/genetics; Female; Humans; Male; Mixed Function Oxygenases/genetics; Mixed Function Oxygenases/metabolism; Molecular Probes; Pharmacogenetics/methods; Polymorphism, Genetic

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Collection: 01-internacional Database: MEDLINE Main subject: Phenotype / Pharmaceutical Preparations / Cytochrome P-450 Enzyme System / Liver Limits: Female / Humans / Male Language: En Journal: J Clin Pharm Ther Year: 2003 Document type: Article

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