A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5.

Tanaka, M; Berul, C I; Ishii, M; Jay, P Y; Wakimoto, H; Douglas, P; Yamasaki, N; Kawamoto, T; Gehrmann, J; Maguire, C T; Schinke, M; Seidman, C E; Seidman, J G; Kurachi, Y; Izumo, S

Tanaka, M; Berul, C I; Ishii, M; Jay, P Y; Wakimoto, H; Douglas, P; Yamasaki, N; Kawamoto, T; Gehrmann, J; Maguire, C T; Schinke, M; Seidman, C E; Seidman, J G; Kurachi, Y; Izumo, S.

Affiliation

Tanaka M; Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Cold Spring Harb Symp Quant Biol ; 67: 317-25, 2002.

Article in En | MEDLINE | ID: mdl-12858555

Subject(s)

Arrhythmias, Cardiac/genetics; Heart Septal Defects, Atrial/genetics; Homeodomain Proteins/genetics; Transcription Factors; Xenopus Proteins; Action Potentials; Animals; Arrhythmias, Cardiac/physiopathology; Disease Models, Animal; Electrophysiology; Heart Septal Defects, Atrial/physiopathology; Heterozygote; Homeobox Protein Nkx-2.5; Homeodomain Proteins/physiology; Humans; In Vitro Techniques; Mice; Mice, Mutant Strains; Myocytes, Cardiac/metabolism; Patch-Clamp Techniques; Potassium/metabolism; Tachycardia, Ventricular/genetics; Tachycardia, Ventricular/physiopathology

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Collection: 01-internacional Database: MEDLINE Main subject: Arrhythmias, Cardiac / Transcription Factors / Homeodomain Proteins / Xenopus Proteins / Heart Septal Defects, Atrial Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cold Spring Harb Symp Quant Biol Year: 2002 Document type: Article

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