Chronic exposure to low levels of antigen in the periphery causes reversible functional impairment correlating with changes in CD5 levels in monoclonal CD8 T cells.

Stamou, Panagiota; de Jersey, James; Carmignac, Danielle; Mamalaki, Clio; Kioussis, Dimitris; Stockinger, Brigitta

Stamou, Panagiota; de Jersey, James; Carmignac, Danielle; Mamalaki, Clio; Kioussis, Dimitris; Stockinger, Brigitta.

Affiliation

Stamou P; Division of Molecular Immunology, The National Institute for Medical Research, London, United Kingdom.

J Immunol ; 171(3): 1278-84, 2003 Aug 01.

Article in En | MEDLINE | ID: mdl-12874216

Subject(s)

Autoantigens/immunology; CD5 Antigens/biosynthesis; CD8-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/metabolism; RNA-Binding Proteins; Adoptive Transfer; Animals; Bone Marrow Cells/immunology; Bone Marrow Cells/metabolism; Bone Marrow Transplantation; Cell Differentiation/genetics; Cell Differentiation/immunology; Clonal Anergy/genetics; Clone Cells; Dose-Response Relationship, Immunologic; Down-Regulation/genetics; Down-Regulation/immunology; Immunophenotyping; Influenza A virus/genetics; Influenza A virus/immunology; Mice; Mice, Transgenic; Nucleocapsid Proteins; Nucleoproteins/biosynthesis; Nucleoproteins/genetics; Nucleoproteins/immunology; Radiation Chimera/immunology; T-Lymphocyte Subsets/immunology; T-Lymphocyte Subsets/metabolism; T-Lymphocyte Subsets/transplantation; Thymus Gland/cytology; Thymus Gland/immunology; Thymus Gland/metabolism; Viral Core Proteins/biosynthesis; Viral Core Proteins/genetics; Viral Core Proteins/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Autoantigens / RNA-Binding Proteins / CD8-Positive T-Lymphocytes / CD5 Antigens Type of study: Etiology_studies Language: En Journal: J Immunol Year: 2003 Document type: Article

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