Drug-induced steatohepatitis.
Clin Liver Dis
; 7(2): 435-51, 2003 May.
Article
in En
| MEDLINE
| ID: mdl-12879993
Drugs rarely cause steatohepatitis, but amiodarone, perhexiline, and DH, have unequivocally been found to independently induce the histologic picture of alcoholic liver disease or NASH. All three agents have similar pathogenetic mechanisms of hepatotoxicity, targeting mitochondrial ATP production and fatty acid catabolism. Other drugs that occasionally cause steatohepatitis, most importantly steroid hormones, likely exacerbate the pathogenetic mechanisms leading to NASH. Similar to NASH, lipid peroxidation resulting from mitochondrial injury may account for all of the histologic findings in drug-induced steatohepatitis. Further research should determine the mechanisms by which drug-induced steatosis, a benign lesion, evolves to steatohepatitis and progressive fibrosis.
Search on Google
Collection:
01-internacional
Health context:
1_ASSA2030
Database:
MEDLINE
Main subject:
Calcium Channel Blockers
/
Antineoplastic Agents, Hormonal
/
Fatty Liver
/
Anti-Arrhythmia Agents
Limits:
Animals
/
Humans
Language:
En
Journal:
Clin Liver Dis
Year:
2003
Document type:
Article