Vasopressin type 1A receptor up-regulation by cyclosporin A in vascular smooth muscle cells is mediated by superoxide.

Krauskopf, Alexandra; Lhote, Philippe; Mutter, Manfred; Dufour, Jean-François; Ruegg, Urs T; Buetler, Timo M

Krauskopf, Alexandra; Lhote, Philippe; Mutter, Manfred; Dufour, Jean-François; Ruegg, Urs T; Buetler, Timo M.

Affiliation

Krauskopf A; Pharmacology Group, School of Pharmacy, University of Lausanne, 1015 Lausanne, Switzerland.

J Biol Chem ; 278(43): 41685-90, 2003 Oct 24.

Article in En | MEDLINE | ID: mdl-12923165

Subject(s)

Cyclosporine/pharmacology; Muscle, Smooth, Vascular/cytology; Receptors, Vasopressin/biosynthesis; Superoxides/pharmacology; Animals; Aorta/cytology; Calcineurin/pharmacology; Catalase/metabolism; Cyclophilins/pharmacology; Free Radicals/metabolism; Male; RNA, Messenger/biosynthesis; RNA, Messenger/drug effects; Rats; Rats, Wistar; Superoxide Dismutase/metabolism; Superoxides/metabolism; Up-Regulation/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Cyclosporine / Receptors, Vasopressin / Superoxides / Muscle, Smooth, Vascular Limits: Animals Language: En Journal: J Biol Chem Year: 2003 Document type: Article

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