Mapping the binding domains of the alpha(IIb) subunit. A study performed on the activated form of the platelet integrin alpha(IIb)beta(3).

Biris, Nikolaos; Abatzis, Morfis; Mitsios, John V; Sakarellos-Daitsiotis, Maria; Sakarellos, Constantinos; Tsoukatos, Demokritos; Tselepis, Alexandros D; Michalis, Lambros; Sideris, Dimitrios; Konidou, Georgia; Soteriadou, Ketty; Tsikaris, Vassilios

Biris, Nikolaos; Abatzis, Morfis; Mitsios, John V; Sakarellos-Daitsiotis, Maria; Sakarellos, Constantinos; Tsoukatos, Demokritos; Tselepis, Alexandros D; Michalis, Lambros; Sideris, Dimitrios; Konidou, Georgia; Soteriadou, Ketty; Tsikaris, Vassilios.

Affiliation

Biris N; Department of Chemistry, University of Ioannina, Ioannina, Greece.

Eur J Biochem ; 270(18): 3760-7, 2003 Sep.

Article in En | MEDLINE | ID: mdl-12950259

Subject(s)

Blood Platelets/chemistry; Blood Platelets/metabolism; Platelet Aggregation/physiology; Platelet Glycoprotein GPIIb-IIIa Complex/chemistry; Platelet Glycoprotein GPIIb-IIIa Complex/metabolism; Adenosine Diphosphate/pharmacology; Amino Acid Motifs/genetics; Amino Acid Sequence; Animals; Antibodies, Monoclonal/metabolism; Binding Sites; Dose-Response Relationship, Drug; Dual Specificity Phosphatase 2; Fibrinogen/chemistry; Fibrinogen/drug effects; Fibrinogen/metabolism; Fluorescein/chemistry; Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Peptides/chemical synthesis; Peptides/metabolism; Peptides/pharmacology; Platelet Activation/drug effects; Platelet Activation/physiology; Platelet Aggregation/drug effects; Platelet Aggregation Inhibitors/pharmacology; Platelet Glycoprotein GPIIb-IIIa Complex/genetics; Protein Binding; Protein Phosphatase 2; Protein Structure, Tertiary; Protein Subunits; Protein Tyrosine Phosphatases/drug effects; Protein Tyrosine Phosphatases/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Blood Platelets / Platelet Aggregation / Platelet Glycoprotein GPIIb-IIIa Complex Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Eur J Biochem Year: 2003 Document type: Article

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