Inhibition of molar eruption and root elongation in MT1-MMP-deficient mice.
Connect Tissue Res
; 44 Suppl 1: 298-9, 2003.
Article
in En
| MEDLINE
| ID: mdl-12952212
ABSTRACT
To study whether eruption of teeth and root growth require remodeling of collagen in the peridental tissues, we studied molar development in mice deficient in MT1-MMP, an enzyme essential for remodeling of soft tissue-hard tissue interfaces. The lower jaws of deficient mice and their wildtype littermates were subjected to stereologic analysis. It was shown that in deficient animals, eruption and root elongation were severely inhibited, signifying a role of the enzyme in these developmental processes.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Periodontal Ligament
/
Tooth Eruption
/
Tooth Root
/
Metalloendopeptidases
Limits:
Animals
Language:
En
Journal:
Connect Tissue Res
Year:
2003
Document type:
Article