Prophylactic diclofenac infusions in major orthopedic surgery: effects on analgesia and acute phase proteins.
Acta Anaesthesiol Scand
; 36(3): 270-5, 1992 Apr.
Article
in En
| MEDLINE
| ID: mdl-1374201
ABSTRACT
The influence of diclofenac, given by continuous i.v. infusion starting preoperatively, on postoperative pain and inflammation was assessed in a double-blind, randomized, placebo-controlled study in 40 patients scheduled for major orthopedic surgery. Starting 30 min before induction the patients received either diclofenac (0.35 mg.kg-1 bolus followed by a constant-rate infusion of 90 micrograms.min-1) or placebo for 24 h. The pain intensity (VAS) and the amount of rescue narcotic (piritramide on demand) were significantly lower in the diclofenac group from 4 and 6 h postsurgery, respectively, till end of infusion. Acute phase proteins used as inflammation markers (C-reactive protein, alpha 1-chymotrypsin, alpha 1-acid glycoprotein, haptoglobin and coeruloplasmin) showed similar variations in both groups for 24 h. The diclofenac treatment had no influence on hematological and coagulation profiles, nor on muscle and liver enzymes in comparison with placebo. Both patients and observer rated the diclofenac treatment as significantly superior to the placebo treatment.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Orthopedics
/
Pain, Postoperative
/
Acute-Phase Proteins
/
Diclofenac
/
Inflammation
Type of study:
Clinical_trials
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Acta Anaesthesiol Scand
Year:
1992
Document type:
Article