Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel: effect of the benzimidazolone derivative NS004.

Dérand, R; Bulteau-Pignoux, L; Becq, F

Dérand, R; Bulteau-Pignoux, L; Becq, F.

Affiliation

Dérand R; Laboratoire des Biomembranes et Signalisation Cellulaire, UMR 6558 CNRS, Université de Poitiers, 86022 Poitiers, France.

J Membr Biol ; 194(2): 109-17, 2003 Jul 15.

Article in En | MEDLINE | ID: mdl-14502435

Subject(s)

Benzimidazoles/pharmacology; Chlorophenols/pharmacology; Cystic Fibrosis Transmembrane Conductance Regulator/drug effects; Cystic Fibrosis Transmembrane Conductance Regulator/physiology; Ion Channel Gating/drug effects; Ion Channel Gating/physiology; Membrane Potentials/drug effects; Membrane Potentials/physiology; Animals; CHO Cells; Colforsin/pharmacology; Cricetinae; Cricetulus; Cystic Fibrosis Transmembrane Conductance Regulator/chemistry; Dose-Response Relationship, Drug; Glycine/metabolism; Mutagenesis, Site-Directed; Mutation; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Ion Channel Gating / Chlorophenols / Cystic Fibrosis Transmembrane Conductance Regulator / Membrane Potentials Limits: Animals Language: En Journal: J Membr Biol Year: 2003 Document type: Article

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