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Bupropion treatment of fluoxetine-resistant chronic fatigue syndrome.
Goodnick, P J; Sandoval, R; Brickman, A; Klimas, N G.
Affiliation
  • Goodnick PJ; Department of Psychiatry, University of Miami, Florida 33136.
Biol Psychiatry ; 32(9): 834-8, 1992 Nov 01.
Article in En | MEDLINE | ID: mdl-1450297
ABSTRACT
Chronic fatigue syndrome (CFS) includes many symptoms of major depression. For this reason, many antidepressants have been used to treat the symptoms of this disorder. Among the more recently released antidepressants are fluoxetine and bupropion. In this open study, nine CFS patients who either could not tolerate or did not respond to fluoxetine showed significant response when administered 300 mg/day of bupropion for an 8-week period in both rating of HDRS (t = 4.80, p < 0.01) and BDI (t = 2.48, p < 0.05). Furthermore, bupropion improvement in Hamilton Depression Rating Scale correlated significantly with change in plasma homovanillic acid (HVA) (r = 0.96, p < 0.01). Plasma total methylhydroxyphenolglycol (MHPG) also increased significantly during bupropion treatment (t = 2.37, p = 0.05). Measures of T1 microsomal antibodies also decreased over treatment time; increases in natural killer cell numbers correlated inversely with change in plasma levels of free MHPG (r = -0.88, p < 0.05). Bupropion responders were more likely to have trough blood levels above 30 ng/ml (chi 2 = 3.6, p = 0.05).
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Fatigue Syndrome, Chronic / Fluoxetine / Bupropion Type of study: Observational_studies / Prognostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Biol Psychiatry Year: 1992 Document type: Article
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Collection: 01-internacional Database: MEDLINE Main subject: Fatigue Syndrome, Chronic / Fluoxetine / Bupropion Type of study: Observational_studies / Prognostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Biol Psychiatry Year: 1992 Document type: Article