Multidrug-resistant tumor cells remain sensitive to a recombinant interleukin-4-Pseudomonas exotoxin, except when overexpressing the multidrug resistance protein MRP1.

de Jong, Mariska C; Scheffer, George L; Broxterman, Henk J; Hooijberg, Jan H; Slootstra, Jerry W; Meloen, Rob H; Kreitman, Robert J; Husain, Syed R; Joshi, Bharat H; Puri, Raj K; Scheper, Rik J

de Jong, Mariska C; Scheffer, George L; Broxterman, Henk J; Hooijberg, Jan H; Slootstra, Jerry W; Meloen, Rob H; Kreitman, Robert J; Husain, Syed R; Joshi, Bharat H; Puri, Raj K; Scheper, Rik J.

Affiliation

de Jong MC; Department of Pathology, VU University Medical Center, 1081 HV Amsterdam, The Netherlands.

Clin Cancer Res ; 9(13): 5009-17, 2003 Oct 15.

Article in En | MEDLINE | ID: mdl-14581376

Subject(s)

Drug Resistance, Multiple; Drug Resistance, Neoplasm; Exotoxins/physiology; Interleukin-4/metabolism; Interleukin-4/physiology; Multidrug Resistance-Associated Proteins/metabolism; Recombinant Proteins/metabolism; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Antimetabolites, Antineoplastic/pharmacology; Antineoplastic Agents/pharmacology; Bacterial Toxins/chemistry; Bacterial Toxins/metabolism; Buthionine Sulfoximine/pharmacology; Cell Line, Tumor; Cell Membrane/metabolism; DNA, Complementary/metabolism; Dose-Response Relationship, Drug; Exotoxins/chemistry; Exotoxins/metabolism; Humans; Interleukin-4/chemistry; Leukotriene Antagonists/pharmacology; Probenecid/pharmacology; Propionates/pharmacology; Quinolines/pharmacology; Transfection; Uricosuric Agents/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Proteins / Interleukin-4 / Drug Resistance, Multiple / Drug Resistance, Neoplasm / Multidrug Resistance-Associated Proteins / Exotoxins Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Clin Cancer Res Year: 2003 Document type: Article

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