Synthesis of 3-aminopyrazinone mediated by 2-pyridylthioimidate-ZnCl2 complexes. Development of an efficient route to a thrombin inhibitor.

Chung, John Y L; Cvetovich, Raymond J; Tsay, Fuh-Rong; Dormer, Peter G; DiMichele, Lisa; Mathre, David J; Chilenski, Jennifer R; Mao, Bing; Wenslow, Robert

Chung, John Y L; Cvetovich, Raymond J; Tsay, Fuh-Rong; Dormer, Peter G; DiMichele, Lisa; Mathre, David J; Chilenski, Jennifer R; Mao, Bing; Wenslow, Robert.

Affiliation

Chung JY; Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. john_chung@merck.com

J Org Chem ; 68(23): 8838-46, 2003 Nov 14.

Article in En | MEDLINE | ID: mdl-14604352

Subject(s)

Antithrombins/chemical synthesis; Chlorides/chemistry; Imidoesters/chemistry; Pyrazines/chemical synthesis; Pyridines/chemistry; Zinc Compounds/chemistry; Antithrombins/chemistry; Magnetic Resonance Spectroscopy; Pyrazines/chemistry

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Pyridines / Chlorides / Antithrombins / Zinc Compounds / Imidoesters Language: En Journal: J Org Chem Year: 2003 Document type: Article

Search on Google

XML

PubMed Links