Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability.

Alam, N A; Gorman, P; Jaeger, E E M; Kelsell, D; Leigh, I M; Ratnavel, R; Murdoch, M E; Houlston, R S; Aaltonen, L A; Roylance, R R; Tomlinson, I P M

Alam, N A; Gorman, P; Jaeger, E E M; Kelsell, D; Leigh, I M; Ratnavel, R; Murdoch, M E; Houlston, R S; Aaltonen, L A; Roylance, R R; Tomlinson, I P M.

Affiliation

Alam NA; Molecular and Population Genetics Laboratory, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3PX, UK. A.Alam@cancer.org.uk

Cancer Genet Cytogenet ; 147(2): 121-7, 2003 Dec.

Article in En | MEDLINE | ID: mdl-14623461

Subject(s)

Colorectal Neoplasms/genetics; Exodeoxyribonucleases/genetics; Genomic Instability; Microsatellite Repeats; Sequence Deletion; Adult; Aged; Colorectal Neoplasms/etiology; DNA Repair Enzymes; Female; Genotype; Haplotypes; Humans; In Situ Hybridization, Fluorescence; Male; Middle Aged; Pedigree

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Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Sequence Deletion / Microsatellite Repeats / Genomic Instability / Exodeoxyribonucleases Type of study: Etiology_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Cancer Genet Cytogenet Year: 2003 Document type: Article

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