Combination therapy of disseminated Fusarium oxysporum infection with terbinafine and amphotericin B.
Ann Hematol
; 83(6): 394-7, 2004 Jun.
Article
in En
| MEDLINE
| ID: mdl-14648020
ABSTRACT
A case of disseminated infection with Fusarium oxysporum following chemotherapy of acute myelogenous leukemia is reported. Antifungal treatment was successful with a 13-day course of oral terbinafine 250 mg t.i.d. in combination with amphotericin B deoxycholate 1.0-1.5 mg/kg qd and subsequently intravenous liposomal amphotericin B 5 mg/kg qd. Preceding monotherapy with amphotericin B deoxycholate 1.0-1.5 mg/kg qd had not stopped the progression of infection. The combination therapy described here represents a novel approach to the treatment of Fusarium spp. in the immunocompromised host in whom Fusarium spp. are known to cause disseminated infection with high mortality.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Amphotericin B
/
Dermatomycoses
/
Fusarium
/
Antifungal Agents
/
Naphthalenes
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Ann Hematol
Year:
2004
Document type:
Article