Direct inhibition of the sodium/hydrogen exchanger after prolonged regional ischemia improves contractility on reperfusion independent of myocardial viability.

Yarbrough, William M; Mukherjee, Rupak; Escobar, G Patricia; Mingoia, Joseph T; Sample, Jeffrey A; Hendrick, Jennifer W; Dowdy, Kathryn B; McLean, Julie E; Stroud, Robert E; Spinale, Francis G

Yarbrough, William M; Mukherjee, Rupak; Escobar, G Patricia; Mingoia, Joseph T; Sample, Jeffrey A; Hendrick, Jennifer W; Dowdy, Kathryn B; McLean, Julie E; Stroud, Robert E; Spinale, Francis G.

Affiliation

Yarbrough WM; Division of Cardiothoracic Surgery, Medical University of South Carolina 29425, USA.

J Thorac Cardiovasc Surg ; 126(5): 1489-97, 2003 Nov.

Article in En | MEDLINE | ID: mdl-14666024

Subject(s)

Guanidines/pharmacology; Myocardial Contraction/drug effects; Myocardial Infarction/pathology; Myocardial Reperfusion Injury/prevention & control; Myocardial Reperfusion/methods; Sodium-Hydrogen Exchangers/antagonists & inhibitors; Sulfones/pharmacology; Animals; Biopsy, Needle; Disease Models, Animal; Female; Heart Function Tests; Hemodynamics; Infusions, Intravenous; Male; Myocardial Contraction/physiology; Myocardial Infarction/surgery; Myocardial Reperfusion/adverse effects; Random Allocation; Recovery of Function; Reference Values; Sensitivity and Specificity; Sodium-Hydrogen Exchangers/pharmacology; Swine; Ventricular Function, Left/drug effects; Ventricular Function, Left/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Sulfones / Myocardial Reperfusion / Myocardial Reperfusion Injury / Sodium-Hydrogen Exchangers / Guanidines / Myocardial Contraction / Myocardial Infarction Type of study: Diagnostic_studies Limits: Animals Language: En Journal: J Thorac Cardiovasc Surg Year: 2003 Document type: Article

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